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Maritime Pine PLUS
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Maritime Pine is a complex of water-soluble, highly bioavailable, antioxidant nutrients extracted from the Maritime Pine tree. It has been one of the hottest selling antioxidants in the United States for the last 9 years. However, the history of Maritime Pine extends for generations. Before Maritime Pine was developed as a dietary supplement, there were reports throughout history of decoctions made from pine bark that healed various ailments. The earliest reports have been traced back to the early 1300s. The most talked about “early discovery” is that of Jacques Cartier’s french expedtition in 1535. His crew was struck with Scurvy while in North America, and the local Indians prepared a pine bark-derived tea that assisted them to recovery within two weeks. In 1966, Dr. Jacques Masquelier read of this story while he was visiting North America, and further research led to his discovery of Leucocyanidol. Our Maritime Pine formulation is unique in the fact that we incorporated the long-term studies of these unique antioxidants along with the latest research available on complimentary compounds to further improve its effectiveness. A unique factor exclusive to Suvida is the inclusion of GSL Minerals, which along with enzymes greatly increase the bioavailability factor. |
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Yes, it is safe. For over five decades, millions of people have regularly taken pine bark extract and the antioxidants in this proven formula. During these many years of use there have been no reported adverse health effects. A popular amount people are taking of the PLUS formulation ranges from about 1 capsule per 20 lbs of body weight to 1 capsule per 50 lbs of body weight each day. For example, a 150 pound person may take anywhere from 3 to 8 capsules per day. Why does this amount vary? It really depends on the reason the person is taking this or any other antioxidant. If the person has a specific need or concern, often the higher amount yields better result. However, if the person is simply taking the product for preventative reasons, a smaller amount may be sufficient. Please remember with ANY supplement you take, if you have any special conditions, please consult your physician. |
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The diverse range of antioxidants in the Maritime Pine PLUS formula does include benefits for Diabetes patients. Specifically R-ALA (Alpha Lipoic Acid) has been tested with for use with Diabetes. Diabetes and Alpha Lipoic Acid: |
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Yes, several ingedients in the PLUS formula have been studied and assist in strengthening the heart and may assist in recovering after a heart event. Alpha lipoic acid and the aging heart
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Yes! Nearly all the antioxidants contained in the plus formulation assist with circulation and improve blood flow. For specific details and research, please refer to the Maritime Pine PLUS Research section under the FAQs (on the right side of the screen) for more details on the PLUS antioxidants. These research links provide details on the individual antioxidant components in PLUS including how they assist circulation and improve blood flow in your body. |
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INGREDIENTS: French Maritime Pine Extract: SuVida uses Premium Sourced French Maritime Pine extract from Dr. Masquelier that for over 50 years has been researched and backed by multiple French, British and American patents.It has been validated via renowned research centers including a highly qualified, independent U.S Universities that put it through 5 analytical methods to ensure efficacy. Cellular Delivery System: Even the best nutrients in the world are of little value if you cannot absorb them at the cellular level. Maritime Pine Plus incorporates unprecedented delivery nutrients, starting with a broad spectrum digestive enzyme blend (amylase, lipase, protease, cellulase, invertase, maltase) and enhanced it with Bioperine™ which is a patented bioavailability enhancer that has clinically demonstrated its ability to increase antioxidant absorption. R-ALA: R-ALA is the purest form of Alpha Lipoic Acid that is up to 12 times more beneficial than regular Alpha Lipoic Acid. Studies by renowned medical centers and researchers have confirmed its benefit in many areas including: Neuropathy, Diabetes, Anti-Aging, Alzheimers, Heart Disease, Parkinson’s, Stroke, Cancer, Aids, and Liver Protection. R-ALA is the only form of Alpha Lipoic Acid that has been proven scientifically to reduce inflammation, increase mitochondrial antioxidant activity, improve memory, protect the brain from neurodegenration associated with aging, enhance glucose transport, protect fats against oxidative damage, chelate harmful metals and reverse stress damage in the heart, and increase other antioxidant activity levels. LeucoSelect®: Has undergone recent research showing it to be a potent antioxidant and free radical scavenger providing important cellular protection. In addition, studies have shown LeucoSelect® to improve microcirculation, enhance poor night vision, reduce swelling and strengthen capillaries as well as connective tissues. LeucoSelect® has been tested in more clinical trials (trials with human subjects) than any other grape seed extract. MirtoSelect™: MirtoSelect™ is the only scientifically proven form of bilberry extract that has demonstrated human benefit for improving vision vascular permeability, edema, hemorrhaging, and issues related to peripheral circulation disorders. This form of Bilberry extract is so effective that it is actually available by prescription in Europe. No detail is left unattended from growing season, conditions, quality of fruit, and ability to rush the berries to a nearby facility before nutrients are diminished. Enzogenol®: Enzogenol is a unique pine bark extract that has undergone
extensive and unique analysis to ensure purity, potency, and diversity.Enzogenol®
is extracted via a patented pure water molecular selection
procedure, and each batch is analyzed for purity and potency. The benefits of Enzogneol® such as decreased joint and arthritic pain
were even featured on a CNN World wide Health Report. Other user-reported benefits include better circulatory
related symptoms, softer skin, thicker/healthier hair, and more energy. |
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The premium nutrients of Maritime Pine PLUS have been studied to benefit:
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Immune support - zinc complex, echinacea/astragalus, garlic, antioxidant complex NoteOther constituents include: flavonoid-type antioxidants such as anthocyanins and proanthocyanidins, pectins, tannins, natural sugars, plant acids, and especially carotenoids. REFERENCES
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Ions play an important role in the body. Larger
minerals such as calcium, potassium, sodium, and chloride are some key ions
that participate in the body's electrical conduction systems. Imbalances of any
of these ions or certain trace ions in the body can negatively affect the
transport of minerals across the cell membranes, leading to dysfunction.
Meanwhile, trace minerals such as chromium, manganese, molybdenum, selenium,
vanadium and copper have very specific effects in the body, and have
far-reaching health effects as evidenced by current research. Chromium Chromium (Cr) is implicated in maintenance of
blood sugar, prevention of atherosclerosis, and control of cholesterol
levels. Human studies suggest that a particular form of chromium known as
chromium picolinate, enhances insulin sensitivity, glucose removal, and may
improve lipid ratios in obese and type 2 diabetics.2
Additionally, it is suggested that chromium has a potential beneficial
antioxidant effect in patients with type 2 diabetes when combined with zinc and
copper supplementation.3
Chromium is found in some foods, in small amounts. Because of this,
supplementation with chromium can have positive health implications. Manganese Manganese (Mn) is a component of several enzyme
systems, including manganese-specific glycosyltransferases and phosphoenolpyruvate
carboxykinase, and is essential for normal bone structure. Unrefined cereals,
green leafy vegetables, and black tea are the richest dietary sources of
manganese. Unfortunately, the refinement of grains has lead to widespread
inadequacies in the daily intake of manganese from our diet. Manganese
deficiency can manifest as transient dermatitis, hypocholesterolemia, and an
increased liver enzyme (alkaline phosphatase) levels. Selenium Selenium (Se) is a part of the enzyme glutathione peroxidase,
which metabolizes free radicals formed from the oxidation of polyunsaturated
fatty acids. Selenium is also a part of the enzymes that deiodinate thyroid
hormones, assisting the body’s use of this hormone. Selenium functions as an
antioxidant that works in conjunction with vitamin E. One study determined that
head and neck cancer patients had serum selenium levels that were significantly
lower compared with controls, and these levels decreased further as their tumor
burden increased.4
Molybdenum Molybdenum (Mo) is a transition metal that forms
oxides and is a component of a coenzyme that is essential for the activity of
xanthine oxidase, sulfite oxidase, and aldehyde oxidase.5
Molybdenum is derived principally from organ meats, whole-grain cereals, and
legumes. Molybdenum may possibly retard degenerative diseases, cancer and
aging. Molybdenum acts as a detoxification agent in the liver as a part of the
sulfite oxidase enzyme, which destroys sulfite, a common preservative in foods
and drugs. Vanadium Vanadium (V) has a significant role in inducing
the production of reduced glutathione content in the liver and specific
extrahepatic tissues.6
Additionally, vanadium increases the activity of the detoxifying enzyme system
glutathione S-transferase in liver and in several extrahepatic tissues.7
Because of vanadium’s ability to induce an increase of detoxifying enzyme
activity, vanadium might be considered a potential cancer chemopreventive
agent. Vanadium appears to function like insulin by altering cell membrane
function for ion transport processes, increasing insulin receptor sensitivity.8
Vanadium may also inhibit cholesterol synthesis in animals and humans resulting
in decreased plasma levels. Copper Copper (Cu) is a universally important cofactor
for many hundreds of enzymes. Copper functions as a co-factor and activator of
numerous enzymes that are involved in the development and maintenance of the
cardiovascular system. Copper is essential for the function of reduced lysyl
oxidase activity, which causes a conversion of the connective tissue element
pro-elastin to elastin. A copper deficiency can result in a decrease in the
tinsel strength of arterial walls, leading to aneurysm formation and skeletal
maldevelopment.9 Other effects of
copper deficiency are anemia (iron storage disease can result from chronic
copper deficiency), poor hair keratinization and hypopigmentation.10
Summary From the examples above, it is
clear that maintaining a balance of ionic minerals in the body is essential to
our health. Minerals provide much of the basic framework from which health is
built and maintained, and mineral supplementation is an obvious choice for
people who are interested in being proactive in their health. As pointed out in
the June 2002 edition of the Journal of the American Medical Association,
everyone needs to supplement with extra nutrients beyond those found in their
daily diets. This is not surprising since over the last 200 years, the average
amount of top soil in the US has dramatically declined from 21 inches to a mere
6 inches. Fueling your body with the sources of minerals and nutrients is
essential to help maintain vibrant health. 1
Dreosti IE. Recommended dietary intakes of iron, zinc, and other inorganic
nutrients and their chemical form and bioavailability. Nutrition 1993
Nov-Dec;9(6):542-5. 2
Cefalu WT, Wang ZQ, Zhang XH, Baldor LC, Russell JC. Oral chromium picolinate
improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4
translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. J Nutr 2002
Jun;132(6):1107-14 3
Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni A. Potential
antioxidant effects of zinc and chromium supplementation in people with type 2
diabetes mellitus. J Am Coll Nutr 2001 Jun;20(3):212-8 4
Yadav SP, Gera A, Singh I, Chanda R. Serum selenium levels in patients with
head and neck cancer. J Otolaryngol 2002 Aug;31(4):216-9 5
Nielsen, Forrest H. Ultratrace Elements of Possible Importance for Human
Health: An Update Essential and Toxic Tace Elements in Human Health: An Update,
pages 355-376, 1993. 6
Bishayee A, Chatterjee M. Time course effects of vanadium supplement on
cytosolic reduced glutathione level and glutathione S-transferase activity.
Biol Trace Elem Res 1995 Jun;48(3):275-285 7
Bishayee A, Chatterjee M. Selective enhancement of glutathione
S-transferase activity in liver and extrahepatic tissues of rat following oral
administration of vanadate. Acta Physiol Pharmacol Bulg 1993;19(3):83-89 8
Shamherger, R.J The Insulin-Like Effects of Vanadium. J of Adv in
Med. Vol. 9, No. 2, Summer 1996 9
Tilson MD. Decreased hepatic copper levels. A possible chemical marker for the
pathogenesis of aortic aneurysms in man. Arch Surg 1982 Sep;117(9):1212-1213 10
Wildman RE, Medeiros DM, Jenkins J Comparative aspects of cardiac
ultrastructure, morphometry, and electrocardiography of hearts from rats fed
restricted dietary copper and selenium. Biol Trace Elem Res 1994
Oct;46(1-2):51-66 |
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It's not what you swallow that counts, it is what you absorb. We first source the most bioactive broad spectrum digestive enzymes which gives a solid base for nutrient absorption. We then couple those enzymes with a patented ingredient which has clinically proven to enhance antioxidant nutrient absorption, including: Vitamin A, Vitamin C, Vitamin E, alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavonoids complex, germanium, selenium and zinc. Besides sourcing top grade nutrients from around the world to ensure maximum nutrient availability and purity, we want to ensure that you are able to absorb those nutrients. This is one of the many reasons why health care professionals and consumers alike from around the world trust SuVida to supply the best formulations available anywhere. Bioperine is a standardized extract from the fruits of Piper nigrum L. (black pepper) or Piper longum L. (long pepper). It contains a minimum piperine content of 95% compared to the 3-9% and 3-5% found in raw forms of Piper nigrum and Piper longum, respectively. Bioperine may be co-administered with various nutrients for human health. The patented form of Bioperine, has been clinically tested in the United States and shown to significantly enhance the bioavailability of various supplemented nutrients through increased absorption. Bioperine activates a metabolic paddle wheel, of sorts, that selectively
provides a more efficient mode of nutrient transportation into the blood. Based
on available research, piperine is unique in its thermonutrient activity. Nutrition Research (1999) 19(3) 381-388 PIPERINE, AN ALKALOID DERIVED FROM BLACK PEPPER, INCREASES SERUM RESPONSE OF BETA-CAROTENE DURING 14-DAYS OF ORAL BETA-CAROTENE SUPPLEMENTATION Vladimir Badmaev, M.D., Ph.D., Muhammed Majeed, Ph.D. and Edward P. Norkus Ph.D. ABSTRACT The effectiveness of an extract from the fruit of black pepper, consisting of a minimum of 98% pure alkaloid piperine was evaluated for its ability to improve serum response of beta-carotene during oral supplementation using a double-blind, crossover study design. Subjects were randomly selected to ingest a daily beta-carotene dose (15 mg) either with 5 mg of piperine or placebo during each of two 14-day supplementation periods. Inter-subject variability in pre-supplementation serum beta-carotene levels was minimized by limiting the selection of volunteers to healthy adult males with fasting serum beta-carotene values < 20 mcg/dL. The results indicate that significantly greater increases (p < 0.0001) in serum beta-carotene occurred during supplementation with beta carotene plus piperine (49.8±9.6 mcg/dL vs. 30.9±5.4 mcg/dL) compared to beta-carotene plus placebo. Supplementation with beta-carotene plus piperine for 14 days produced a 60% greater increase in area under the serum beta- carotene curve (AUC) than was observed during supplementation with beta-carotene plus placebo. We suggest that the serum response during oral beta-carotene supplementation is improved through non-specific, thermogenic property(s) of piperine described in this paper as thermonutrient action. J. Nutr. Biochem. (2000) 11: 109-113 Vladimir Badmaev, M.D., Ph.D., Muhammed Majeed, Ph.D., and Lakshmi Prakash, Ph.D. An extract from the fruits of black pepper consisting of a minimum of 98% pure
piperine was evaluated in a clinical study using a double-blind design. The
relative bioavailability of 90 mg and 120 mg of coenzyme Q10
administered in a single dose experiment or in separate experiments for 14 and
21 days with placebo or with 5 mg of piperine was determined by comparing
measured changes in plasma concentration. The inter-subject variability was
minimized by limiting the selection of individuals to healthy adult male
volunteers with (pre-supplementation) fasting coenzyme Q10 values
between 0.30 and 0.60 mg/L. The results of a single dose study and the 14-day
study indicate smaller, but not significant, increases in plasma concentrations
of coenzyme Q10 in the control group compared to the group receiving
coenzyme Q10 with a supplement of piperine. Supplementation of 120
mg of coenzyme Q10 with piperine for 21 days produced a
statistically significant (p=0.0348), approximately 30% greater, area under the
plasma curve (AUC) than observed during supplementation with coenzyme Q10
plus placebo. It is postulated that the bioenhancing mechanism of piperine to
increase plasma levels of supplemental coenzyme Q10 is nonspecific
and possibly based on its description in the literature as a thermonutrient. |
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Enzogenol is a powerful and highly effective formulation of antioxidants extracted from fresh New Zealand pine bark - the most comprehensive complex of natural antioxidants yet discovered. A breakthrough in processing technology combines all of these antioxidants in an Enzogenol capsule in exactly the same ratios as are present in the tree's bark. What's more, the revolutionary pure-water extraction process doesn't use toxic solvents like traditional extraction processes do. Enzogenol, health and well-being The role of antioxidants on human health is vital, and their importance in contributing to optimal health is becoming more recognized. Most people take Enzogenol to improve their dietary balance of a wide range of important flavonoids and help prevent the onset of age-related diseases such as coronary heart disease, cancer, diabetes, Alzheimer's, and Parkinson's disease. Elevated levels of oxidative stress have been implicated in these and many other conditions. Regular Enzogenol users enjoy an enhanced feeling of well-being and energy. Disclaimer: Enzogenol is not intended as a treatment for any disease. It is a supplement to the diet, which may well alleviate a shortage of critical flavonoid compounds in your body Enzogenol dosage Dosage depends on the individual. Our normal flavonoid intake is believed to be between 23-170mg/day and this inadequate amount is due to our low consumption of fresh fruit and vegetables. Evolutionary biologists believe that when humans relied on hunting and gathering, they consumed far higher quantities of dietary flavonoids. Healthy individuals with balanced diets will require around 50-200mg per day of Enzogenol to help prevent the onset of degenerative diseases. Those with chronic conditions and/or other factors - such as age - that lead to higher levels of oxidative stress have found higher dosage rates more beneficial. Safety Enzogenol has been shown to
be safe in a series of clinical studies. It has been widely sold
in a number of countries with virtually no adverse reactions. As with any food
or supplement, an individual may experience an adverse reaction. Should this
occur, you should stop taking the product. The effects of flavonoids on coronary heart disease (CHD) Dietary flavonoids have
been shown to have a positive impact on coronary heart disease. This disease is
one of the biggest killers in the western world, and developments in
cardiovascular disease research have shown that oxidative reactions and free
radicals play a role in myocardial injury and atherogenesis. THE QUALITIES OF PINE BARK: Trees have survived the ravages of the environment for millions of years - due in no small part to nature's ultimate defense system, humble tree bark. Bark is a rich source of particularly active antioxidants called flavonoids, and the bark of Pinus radiata provides the most comprehensive mix of antioxidants ever discovered. It is only natural that trees have evolved a defense system stronger than those of fruits and vegetables - mostly "one season wonders". Enzogenol provides an unprecedented encapsulation of the pine tree's natural defense mechanism, by extracting a full spectrum of naturally occurring compounds from the pine bark - through groundbreaking processing technology that uses only pure water in the extraction process. It is this patented technology that enables Enzogenol to contain exactly the same ratios of significant groups of antioxidants that exist inside the pine bark itself - to provide the same level of antioxidant protection to humans that pine bark has provided to Pinus radiata for more than 250 million years. Pinus radiata - a sustainable source Pinus radiata (also known as Monterey Pine) is grown sustainably throughout New Zealand in the pure soil, water and air of New Zealand's sub-alpine conditions, in the absence of pesticides and chemical fertilisers. This tree has flourished in New Zealand and is the country's most dominant species, with more than 1.6 million hectares of planted forest. Only radiata bark of a certain age, from a particular portion of the tree and free from contaminants, is accepted for extraction into Enzogenol. The bark is peeled off logs freshly harvested from a specialist forest, transported immediately to the Enzogenol production facility, ground, thoroughly screened and then washed in pure water that has been de-ionised, filtered and cleared of all oxidants. Bark as a traditional medicine Down through the ages, trees have provided abundantly for humans. They have been a source of wood for shelter, transport, weapons of war and instruments of cultivation, not to mention fuel for cooking and heating. Trees also provide many different foods: apples, pears, figs, citrus, coconuts, mangoes and dates to name a few of the most common. Trees, particularly bark, have provided traditional remedies for ailments in many of the world's cultures:
Many treatments recognised by modern western culture originated from trees: quinine for malaria, and the active ingredient of aspirin which was first isolated from the bark of the white willow tree. Today's medicine also turns to trees and bark to treat cancer: Taxol (trade name for paclitaxel), a compound found in the bark of the Pacific Yew, has shown positive results in the treatment of breast cancer. Many other trees contain cancer-fighting substances. Bark is a rich source of flavonoids and has been used for many years in medicine. It is complex in its chemistry and physical structure, containing literally hundreds of compounds. All of these compounds work synergistically to protect the tree from insects, pests and fungal diseases. We are only beginning to understand the immense complexity and richness of the many compounds in tree bark. CLINICAL FINDINGS: Living Longer - a study These studies aimed to determine the effects of Enzogenol on ageing, health and well-being. Mice were used in the experiment because, like humans, they develop degenerative diseases as they age. Much of this degeneration is thought to be due to the action of free radicals attacking cells and tissues in the body, as well as interfering with regenerative processes. These studies revealed that Enzogenol not only slowed down these degenerative processes in mice, it also helped the mice to live longer and healthier lives. Toxicity - No acute or chronic toxicity of Enzogenol was evident in any of the trials. Effects on general condition - Mice fed Enzogenol grew thicker, glossier fur; their eyes became brighter and their noses and tails pinker - a sure sign of healthy mice! When asked to pick the healthiest looking mice, independent observers invariably identified the mice that were fed Enzogenol over the control groups. Effects on longevity - If the mouse results serve as a good model for humans, then a normal dose of Enzogenol increases the number of people who survive to a given old age, X, by 1.825 times. In other words, trial results show that old age survival to age X is nearly doubled due to Enzogenol. Of the mice given Enzogenol during these trials: * There was no evidence of
acute toxicity Most significantly, it prolonged the quantity and quality of life. On the basis of these mice trial results, two classes of effects were observed: Alpha (a) Effects - Alpha effects are the long-term effects of scavenging or neutralizing of free radicals. These effects do not change the way that people feel. The antioxidant is taken in the expectation it will prevent disease, cancer, heart attacks etc. There is no obvious change - which could explain the longevity and reduced tumor incidence in the mice. Beta (ß) Effects - Beta effects are noticed more quickly. These are the changes that you notice in health, psychological or emotional state, or that others notice in you. In this case the antioxidant is affecting metabolic processes with subsequent changes in physical, emotional or physiological state. Beta effects cause increased alertness, improved skin condition, less flu’s and colds, faster recovery from soft tissue damage, improvement in joint movements and an increased ability to cope with stress. These may be the more compelling reasons for taking a powerful antioxidant. For additional details and research data on Enzogenol please visit our
Enzogenol products page and the associated data and research links. |
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MIRTOSELECT DETAILED ANALYSIS Vaccinium myrtillus L. is a deciduous small shrublet belonging to the Ericaceae family, which grows on hilly and mountainous regions of Europe, Asia and North America. The genus Vaccinium comprises nearly 200 species, but it is beyond doubt Vaccinium myrtillus has been written about since the Middle Ages due to its many and varied therapeutic applications in traditional medicine. Several compounds belonging to different chemical classes have been isolated from Vaccinium myrtillus berries and particularly the pharmacological and clinical activities of anthocyanosides have been deeply and well documented in scientific literature. Unprecedented
Technology = Absolute Efficacy Mirtoselect® is obtained exclusively from Vaccinium
myrtillus and flavonoids, specifically anthocyanosides, constitute the
bilberry's active fraction. PHARMACOKINETIC DATA Mirtoselect® is well absorbed by the oral route,
giving plasma levels sufficiently elevated to guarantee the biological effects (1,2). PHARMACOLOGICAL
ACTIVITIES The pharmacological effects of anthocyanosides are mainly evident on microcirculation where different activities have been reported: Vasoprotective action · stimulation of the biosynthesis of mucopolysaccharides, constituents of perivascular tissues, where are recognised as playing an important role in maintaining the integrity of microvessels (4); · inhibition of proteolytic enzymes, such as elastase, which are involved in the degradation of collagen and other components of the extravascular matrix of the smallest blood vessels (5); · antioxidant activity that gives protection to the integrity of microvessels against free radicals damages, particularly after ischemia - reperfusion injury in the microvascular network (6). These effects prevent the formation and promote the regression of hard
exudates (index of altered permeability of capillaries) and microhaemorrhages
(index of altered resistance of capillaries) in some tissues (such as the
retina) where the microvascular network is significantly compromised during
very common pathologies (diabetes, arterial hypertension). Activation of arteriolar vasomotion Stimulation of regeneration rate of rhodopsin CLINICAL EFFICACY The results of pharmacological tests on anthocyanosides have suggested further clinical studies to evaluate the efficacy of Mirtoselect® in the treatment of microvascular disorders in ophthalmology and phlebology. In addition, the potential ability of anthocyanosides in sight improvement has been investigated in adults and children suffering from ocular fatigue due to overuse of eyes. Mirtoselect® in diabetic and hypertensive retinopathy Ophthalmoscopic examinations, including fundus fluorescin angiography performed both before and after the study, showed a significant reduction of retinal microhaemorrhages and a regression of retinal localised oedema following treatment with bilberry extract (10,11). These findings confirm the vasoprotective properties of anthocyanosides from Vaccinium myrtillus by clinical investigations. Mirtoselect® and visual acuity Mirtoselect® in chronic venous
insufficiency of the lower limbs SAFETY Preclinical studies in animals on acute and chronic toxicity
have shown that Mirtoselect® has an excellent safety and
tolerability profile. In dogs, a single oral dose of 3,000 mg/kg did not induce
any sign of adverse effects as well as the oral administration of 80-320 mg/kg
daily over a period of six months (1). THERAPEUTIC The pharmacological and clinical findings suggest several clinical applications of Mirtoselect® in ophthalmology and phlebology: · Treatment of fragility and altered permeability in the microvascular network of the retina associated with diabetes and arterial hypertension. The vasoprotective activity promotes the regression or disappearance of retinal microhaemorrhages and exudates, counteracting the progress of retinopathy. · Treatment of ocular fatigue due to excessive stimulus of light over long hours for example by heavy PC or TV monitor screen viewing or in myopic patients with a decline in visual function due to overuse of the eyes. In fact, anthocyanosides from Vaccinium myrtillus restore vision in a rapid manner accelerating resynthesis of rhodopsin present on the retina, a chromoprotein with a pivotal function in recognizing the things visually. In addition, Mirtoselect® increases the blood supply to the retina, apporting in this way a big amount of nutrients for its functionality. · Treatment of symptoms associated with chronic venous insufficiency of the lower limbs. Mirtoselect® provides a rapid relief of limb oedema, feeling of heaviness, cramp-like pain, thanks to the reduction of capillary permeability and a vasoprotective action. COMPATIBILITY WITH OTHER NUTRITIONAL INGREDIENTS Mirtoselect®'s anthocyanosides can be used to produce multicomponent formulations containing other active substances (i.e vitamin E, vitamin C, ß-carotene, flavonoids from other sources) for a synergic vasoprotective action on microcirculation. For restoring vision it may be interesting to associate anthocyanosides with agents that act synergically in accelerating the resynthesis of rhodopsin (i.e. ß-carotene or vitamin A). CONCLUSIVE REMARKS Numerous studies have been conducted to identify the pharmacological activities of anthocyanosides from Vaccinium myrtillus berries and to assess their clinical efficacy. Most pivotal studies have been carried out with Mirtoselect®, a standardized bilberry fruit extract containing 36% anthocyanosides. Therefore, Mirtoselect® is the only bilberry extract with proven efficacy. Pharmacological studies have shown that Mirtoselect® is effective in increasing capillary resistance, reducing abnormal vascular permeability and performing antioxidant activity at vascular level. These pharmacological findings have suggested a clinical application in the treatment of vascular disorders of the retina due to diabetes and hypertension (retinopathy) and in the management of symptoms associated with chronic venous insufficiency. Several randomized, double-blind and placebo-controlled clinical trials have clearly shown the significant efficacy of Mirtoselect® in hundreds of patients treated. In addition, Mirtoselect® promotes the resynthesis of retinal pigments (rhodopsin) and there is clinical evidence that the intake of bilberry extract is useful for the recovery of visual acuity and relief of eye fatigue symptoms in case of eye overuse. REFERENCES
1) Morazzoni P. et al. Fitoterapia, Volume LXVII - N.1, 1996 |
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Previous studies have found that the major
polyphenol in green tea extracts, epigallocatechin gallate (EGCG), has
chemopreventive effects on cancers affecting a number of organs in the
digestive tract. The team from the
Harvard Medical School reported that EGCG inhibits the growth and reproduction
of cancer cells (SEG-1 and BIC-1)associated with Barrett’s esophagus. Barrett’s
esophagus is a condition caused by stomach acid creeping back up from the
stomach. The acid damage causes the cells lining the esophagus to change and
raises the risk of esophageal cancer by 30 to 40 times. The researchers
concluded that exposure to EGCG induces apoptosis, or programmed cell death,
and results in increased levels of the proteins caspase-3 and cleaved
poly-ADP-ribose polymerase (PARP), known to play a role in DNA damage repair. In the study (abstract
103982), the adenocarcinoma cells were treated with different concentrations of
EGCG and monitored for cell growth, method of cell death and changes in
apoptotic protein levels. Treatment of cells with EGCG inhibited cell growth
and caused signs of early apoptosis at 24 hours. “Research suggests that
drinking green tea may be both a valuable chemopreventive therapy as well as a
treatment for esophageal adenocarcinoma,” said Howard Chang, an investigator of
the study. A recent study, also
presented at Digestive Disease Week, has linked
the increasing prevalence of cancer of the esophagus to growing consumption of
sodas. Green
tea's popularity in the United States continues to grow. Scientific information
that suggests it is a rich, natural source of antioxidants. The following
information provides highlights of green tea's health benefits, and is
accompanied by a comprehensive list of more than 500 green tea studies
conducted over the past several years. |
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